Published On: Wed, Feb 3rd, 2016

Elevated Lactate Levels are Associated with Increased ICU Mortality

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The aimof this study was to better understand the predictive value of lactate in an intensive care setting. In conclusion, patients with high initial lactate were sicker on average than those with low initial lactate, they had longer ICU stays, and were more likely to have poor outcomes.

This study corresponds to the thesis carried out by Hilary G. Mulholland for the Master of Engineering in Computer Science and Molecular Biologypara completed at the Massachusetts Institute Of Technology. The study was written with the title “Understanding Lactate in an Intensive Care Setting”.

To support the author´s conclusions that patients with high initial lactate were sicker on average than those with low initial lactate, she looked at average severity scores of these populations. Admissions with low initial lactate had on average lower SOFA (Sequencial Organ Failure Assessment) scores and lower SAPS I (Simplified Acute Physiology Score) scores than admissions with high initial lactate.

A higher severity score indicates that an illness is more severe and there is a greater likelihood of a poor outcome. Patients with higher initial lactate had higher severity scores which supported our original conclusion that in general patients with very high initial lactate levels had worse outcomes and were sicker than patients with low initial lactate levels.

More information available at Laktate.

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